Histone H2A.X gene transcription is regulated differently than transcription of other replication-linked histone genes.

@article{Bonner1993HistoneHG,
  title={Histone H2A.X gene transcription is regulated differently than transcription of other replication-linked histone genes.},
  author={W. M. Bonner and C Mannironi and Ann H Orr and Duane R. Pilch and Craig L Hatch},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 2},
  pages={984-92}
}
Histone H2A.X is a replication-independent histone H2A isoprotein species that is encoded by a transcript alternatively processed at the 3' end to yield two mRNAs: a 0.6-kb mRNA ending with the stem-loop structure characteristic of the mRNAs for replication-linked histone species, and a second, polyadenylated 1.6-kb mRNA ending about 1 kb further downstream (C. Mannironi, W. M. Bonner, and C. L. Hatch, Nucleic Acids Res. 17:9113-9126, 1989). Of the two, the 0.6-kb H2A.X stem-loop mRNA… CONTINUE READING

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