Histone H2A variants in nucleosomes and chromatin: more or less stable?

  title={Histone H2A variants in nucleosomes and chromatin: more or less stable?},
  author={Clemens B{\"o}nisch and Sandra B Hake},
  booktitle={Nucleic acids research},
In eukaryotes, DNA is organized together with histones and non-histone proteins into a highly complex nucleoprotein structure called chromatin, with the nucleosome as its monomeric subunit. Various interconnected mechanisms regulate DNA accessibility, including replacement of canonical histones with specialized histone variants. Histone variant incorporation can lead to profound chromatin structure alterations thereby influencing a multitude of biological processes ranging from transcriptional… CONTINUE READING

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