Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

  title={Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression},
  author={Reinhard Kalb and Sebastian Latwiel and H. Irem Baymaz and Pascal W. T. C. Jansen and Christoph W M{\"u}ller and Michiel Vermeulen and J{\"u}rg M{\"u}ller},
  journal={Nature Structural &Molecular Biology},
A key step in gene repression by Polycomb is trimethylation of histone H3 K27 by PCR2 to form H3K27me3. H3K27me3 provides a binding surface for PRC1. We show that monoubiquitination of histone H2A by PRC1-type complexes to form H2Aub creates a binding site for Jarid2–Aebp2–containing PRC2 and promotes H3K27 trimethylation on H2Aub nucleosomes. Jarid2, Aebp2 and H2Aub thus constitute components of a positive feedback loop establishing H3K27me3 chromatin domains. 
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