Histone H2A C-Terminus Regulates Chromatin Dynamics, Remodeling, and Histone H1 Binding

@inproceedings{Vogler2010HistoneHC,
  title={Histone H2A C-Terminus Regulates Chromatin Dynamics, Remodeling, and Histone H1 Binding},
  author={Christine Vogler and Claudia Huber and Tanja Waldmann and Ramona Ettig and Lora Braun and Annalisa Izzo and Sylvain Daujat and Isabelle Chassignet and Andr{\'e}s J L{\'o}pez-Contreras and Oscar Fern{\'a}ndez-Capetillo and Miroslav Dundr and Karsten Rippe and Gernot L{\"a}ngst and Robert H. Schneider},
  booktitle={PLoS genetics},
  year={2010}
}
The tails of histone proteins are central players for all chromatin-mediated processes. Whereas the N-terminal histone tails have been studied extensively, little is known about the function of the H2A C-terminus. Here, we show that the H2A C-terminal tail plays a pivotal role in regulating chromatin structure and dynamics. We find that cells expressing C-terminally truncated H2A show increased stress sensitivity. Moreover, both the complete and the partial deletion of the tail result in… CONTINUE READING

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