Histone H1 in nuclei of butyrate-treated murine lymphosarcoma cells has increased affinity for heparin.

Nuclei from butyrate-treated murine lymphosarcoma cells were incubated with different amounts of the polyanion heparin, which is known to interact predominantly with chromatin-associated histones. Unlike isolated histone H1, histone H1 in the nuclei of butyrate-treated cells was found to display an enhanced affinity for the binding to heparin as compared to… CONTINUE READING