Histone H1 and the origin of protamines.

@article{Lewis2004HistoneHA,
  title={Histone H1 and the origin of protamines.},
  author={John D. Lewis and N{\'u}ria Saperas and Yue Song and Maria Jose Zamora and Manel Chiva and Juan Ausi{\'o}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 12},
  pages={4148-52}
}
We present evidence that chordate protamines have evolved from histone H1. During the final stages of spermatogenesis, the compaction of DNA in many organisms is accomplished by the replacement of histones with a class of arginine-rich proteins called protamines. In other organisms, however, condensation of sperm DNA can occur with comparable efficiency in the presence of somatic-type histones or, alternatively, an intermediate class of proteins called protamine-like proteins. The idea that the… CONTINUE READING