Histone H1; A neuronal protein that binds bacterial lipopolysaccharide

@article{Bolton1997HistoneHA,
  title={Histone H1; A neuronal protein that binds bacterial lipopolysaccharide},
  author={Sarah J. Bolton and V Hugh Perry},
  journal={Journal of Neurocytology},
  year={1997},
  volume={26},
  pages={823-831}
}
Bacterial lipopolysaccharide (LPS) is a potent inflammogen following systemic infection. Macrophages express a number of surface molecules including CD14, CD18 and the scavenger receptor that are capable of recognizing and binding LPS. Injection of the CNS with LPS produces an atypical inflammatory response including a delay in the recruitment of macrophages to the brain parenchyma. We have shown using a ligand blot overlay approach, that LPS is capable of binding to histone H1 present in brain… CONTINUE READING
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