Histone Deacetylases with Antagonistic Roles in Saccharomyces cerevisiae Heterochromatin Formation.


As the only catalytic member of the Sir-protein gene-silencing complex, Sir2's catalytic activity is necessary for silencing. The only known role for Sir2's catalytic activity in Saccharomyces cerevisiae silencing is to deacetylate N-terminal tails of histones H3 and H4, creating high-affinity binding sites for the Sir-protein complex, resulting in… (More)
DOI: 10.1534/genetics.116.190835


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