Histone Deacetylase Inhibitors

@article{Ma2009HistoneDI,
  title={Histone Deacetylase Inhibitors},
  author={Xujun Ma and Hany H. Ezzeldin and Dr Robert B. Diasio},
  journal={Drugs},
  year={2009},
  volume={69},
  pages={1911-1934}
}
Histone deacetylase (HDAC) inhibitors are a new group of anticancer agents that have a potential role in the regulation of gene expression, induction of cell death, apoptosis and cell cycle arrest of cancer cells by altering the acetylation status of chromatin and other non-histone proteins. In clinical trials, HDAC inhibitors have demonstrated promising antitumour activity as monotherapy in cutaneous T-cell lymphoma and other haematological malignancies. In solid tumours, several HDAC… CONTINUE READING

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