Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling

@inproceedings{Zhang2015HistoneDI,
  title={Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling},
  author={Peng Zhang and Zhiyong Guo and Ying Wu and Ronglin Hu and Jun Du and Xiao-shun He and Xingyuan Jiao and Xiaofeng Zhu and Wei-Guo Zhu},
  booktitle={PloS one},
  year={2015}
}
Gallbladder carcinoma is an aggressive malignancy with high mortality mainly due to the limited potential for curative resection and its resistance to chemotherapeutic agents. Here, we show that the histone deacetylase inhibitors (HDACIs) trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA) reduce the proliferation and induce apoptosis of… CONTINUE READING