Histone Deacetylase Inhibitors : Updated Studies in Various Epigenetic-Related Diseases

@inproceedings{Zwergel2017HistoneDI,
  title={Histone Deacetylase Inhibitors : Updated Studies in Various Epigenetic-Related Diseases},
  author={Clemens Zwergel and Giulia Stazi and Sergio Valente and Antonello Mai},
  year={2017}
}
Overexpression of Histone deacetylases as key players in mediating gene expression have been demonstrated to be involved in numerous types of cancer and some isoforms also in neurological, inflammatory and viral pathologies. There is large evidence that histone deacetylase inhibitors can be applied for their treatment. This review summarizes recent clinical aspects and efforts in the drug development of histone deacetylase inhibitors and their potential use in therapy. Not only novel potent and… CONTINUE READING

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