Histone Deacetylase 5 Limits Cocaine Reward through cAMP-Induced Nuclear Import

@article{Taniguchi2012HistoneD5,
  title={Histone Deacetylase 5 Limits Cocaine Reward through cAMP-Induced Nuclear Import},
  author={Makoto Taniguchi and Maria B. Carreira and Laura N. Smith and Benjamin C. Zirlin and Rachael Lee Neve and Christopher W Cowan},
  journal={Neuron},
  year={2012},
  volume={73},
  pages={108-120}
}
Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of HDAC5 requires a signaling mechanism that involves transient, protein phosphatase 2A (PP2A)-dependent dephosphorylation of a Cdk5 site (S279) found within the HDAC5 nuclear… CONTINUE READING
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