Histone Acetylation and CREB Binding Protein Are Required for Neuronal Resistance against Ischemic Injury


Epigenetic transcriptional regulation by histone acetylation depends on the balance between histone acetyltransferase (HAT) and deacetylase activities (HDAC). Inhibition of HDAC activity provides neuroprotection, indicating that the outcome of cerebral ischemia depends crucially on the acetylation status of histones. In the present study, we characterized… (More)
DOI: 10.1371/journal.pone.0095465


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