Histone ADP-ribosylation in DNA repair, replication and transcription.

  title={Histone ADP-ribosylation in DNA repair, replication and transcription.},
  author={Simon Messner and Michael O Hottiger},
  journal={Trends in cell biology},
  volume={21 9},
Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ribosylation has often been restricted to functions of the modifying enzymes, rather than to histones as ADP-ribose acceptors. In particular, the identification of specific lysine residues as ADP… CONTINUE READING

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