• Corpus ID: 14777483

Histomorphometry of the human optic nerve.

@article{Jonas1990HistomorphometryOT,
  title={Histomorphometry of the human optic nerve.},
  author={Jost Bruno Jonas and J A M{\"u}ller-Bergh and Ursula Schl{\"o}tzer-Schrehardt and Gottfried O. H. Naumann},
  journal={Investigative ophthalmology \& visual science},
  year={1990},
  volume={31 4},
  pages={
          736-44
        }
}
This study was undertaken to measure number, diameter and distribution of nerve fibers in normal human optic nerves. [] Key Method Twenty-two optic nerves of 19 subjects aged between 20 and 75 years were histomorphometrically examined using semithin sections obtained in a distance of 2 to 5 mm behind the globe. The mean nerve fiber count was 1,159,000 +/- 196,000 with a minimum of 816,000 and a maximum of 1,502,000. The significant (P = 0.025) loss per year of age was approximately 5426 nerve fibers. For…

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References

SHOWING 1-10 OF 39 REFERENCES
The number and diameter distribution of axons in the monkey optic nerve.
TLDR
The observation that higher fiber density and smaller mean fiber diameter are skewed toward the inferior pole appears to coincide with the inferior position of the fovea with respect to the optic nerve head has importance for interpretation of pathologic changes in the optic disc.
The effect of age on normal human optic nerve fiber number and diameter.
Quantitative histology of optic nerve, optic tract and lateral geniculate nucleus of man.
TLDR
Quantitative data of nerve fibre and cell counts in the optic nerve, optic tracts and lateral geniculate nuclei in a case of unilateral enucleation is presented and conclusions are drawn as to the density distribution patterns of nerve fibres and cells in this portion of the visual system as well as the ratio of crossed to uncrossed fibres in the optics chiasma.
Optic disc morphometry in simple optic nerve atrophy
TLDR
Characteristics of SONA were: decreased visibility of the parapapillary retinal nerve fibers, diminished retinal vessel diameter, and area with pallor larger than area with cupping, and distinctness of a tesselated fundus, frequency of optic disc haemorrhages and frequency of bared circumlinear or bared cilioretinal vessels did not differ significantly.
Pseudoglaucomatous physiologic large cups.
Chronic glaucoma selectively damages large optic nerve fibers.
TLDR
Fibers larger than the normal mean diameter atrophied more rapidly in glaucomatous eyes, though no fiber size was spared from damage, and larger fibers were lost preferentially even in areas of the optic nerve with mild damage, indicating their inherent susceptibility to injury byglaucoma.
Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes.
TLDR
Four hundred and fifty-seven unselected normal human optic nerve heads of 319 subjects were evaluated by magnification-corrected morphometry of optic disc photographs, finding that the cup was significantly larger in discs with steep "punched-out" cups and neuroretinal rim area was broadest in the inferior optic disc region.
Nerve fiber layer of the primate retina: morphometric analysis.
  • T. Ogden
  • Medicine
    Investigative ophthalmology & visual science
  • 1984
TLDR
The organization of the retinal nerve fiber layer of the cynomolgus monkey was studied by electron microscopy and variation in spectra among nasal, arcuate, and papillomacular bundles was examined.
Ultrastructure of intraorbital portion of human and monkey optic nerve.
TLDR
Optic nerve ultrastructure was studied in nine humans and 11 monkeys and found that all axons of the optic nerve itself are myelinated, and blood vessels are confined to the connective tissue of the septa and the pia mater.
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