Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue: an ex vivo study

@article{Salvatore2015HistologicalSO,
  title={Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue: an ex vivo study},
  author={S. Salvatore and U. Leone Roberti Maggiore and S. Athanasiou and M. Origoni and M. Candiani and A. Calligaro and N. Zerbinati},
  journal={Menopause},
  year={2015},
  volume={22},
  pages={845–849}
}
ObjectiveMicroablative fractional CO2 laser has been proven to determine tissue remodeling with neoformation of collagen and elastic fibers on atrophic skin. [...] Key Method MethodsThis is a prospective ex vivo cohort trial. Consecutive postmenopausal women with vulvovaginal atrophy managed with pelvic organ prolapse surgical operation were enrolled. After fascial plication, the redundant vaginal edge on one side was treated with CO2 laser (SmartXide2; DEKA Laser, Florence, Italy).Expand

Paper Mentions

Interventional Clinical Trial
Women with genitourinary syndrome of menopause, overactive bladder, with breast or endometrial cancer are randomized to either laser treatment og sham treatment for 3 months. The… Expand
ConditionsBladder, Overactive, Breast Cancer, Endometrial Cancer, (+3 more)
InterventionDevice, Procedure
Interventional Clinical Trial
Subjects with vulvar lichen sclerosus (VLS) will undergo fractional carbon dioxide (CO2) laser treatment to the vulvar area. Subjects will be evaluated for changes in clinical signs… Expand
ConditionsVulvar Lichen Sclerosus
InterventionDevice
Interventional Clinical Trial
Vulvodynia is a debilitating chronic vulvar pain lasting at least 3 months without a clear identifiable cause that is challenging to treat effectively. Vulvodynia is a common pain… Expand
ConditionsVestibulodynia
InterventionDevice
Interventional Clinical Trial
The study will examine the effects of fractional/pixel CO2 laser treatment in vaginal atrophy and in vulvar lichen sclerosus by means of histological and immuno-histochemical… Expand
ConditionsLichen Sclerosus, Vaginal Atrophy
InterventionDevice
Fractional CO2 Laser: From Skin Rejuvenation to Vulvo-Vaginal Reshaping.
TLDR
Fractional micro-ablative CO2 laser seems to reduce symptoms related to vaginal atrophy and is a minimally invasive procedure that stimulates internal tissues of the female lower genital tract to regenerate the mucosa, improving tissue trophism and restoring the correct functionality. Expand
Fractional CO2 laser treatment effect on cervicovaginal lavage zinc and copper levels: a prospective cohort study
TLDR
Fractional CO 2 laser treatment of the vagina impacts CVL zinc and copper levels differently, and zinc levels were significantly higher after the second treatment before returning to baseline values. Expand
Fractional CO2 Laser for Treatment of Vulvovaginal Atrophy: A Short Time Follow-up
TLDR
It seems vaginal fractional CO2 laser can be applied as an effective and safe treatment method in genitourinary syndrome of menopause (GSM), it is necessary to conduct studies with long-term follow-up. Expand
The use of pulsed CO2 lasers for the treatment of vulvovaginal atrophy.
TLDR
Increasing evidence with histological and clinical data supports the use of pulsed CO2 lasers in the treatment of VVA; however, no randomized control trial has yet been produced and no data on the duration of therapy are currently available. Expand
The use of pulsed CO2 lasers for the treatment of vulvovaginal atrophy
TLDR
Increasing evidence with histological and clinical data supports the use of pulsed CO2 lasers in the treatment of VVA; however, no randomized control trial (sham versus treatment) has yet been produced and no data on the duration of therapy are currently available. Expand
The effect of microablative fractional CO2 laser on vaginal flora of postmenopausal women
TLDR
MFCO2-Laser therapy is a promising treatment for improving the vaginal health of postmenopausal women by helping repopulate the vagina with normally existing Lactobacillus species and reconstituting the normal flora to premenopausal status. Expand
Fractional CO2 laser treatment for vulvovaginal atrophy symptoms and vaginal rejuvenation in perimenopausal women
  • C. Arroyo
  • Medicine
  • International journal of women's health
  • 2017
TLDR
Fractional CO2 laser treatment was associated with improvement of vaginal health and amelioration of symptoms of VVA, resulting in improved sexual function in perimenopausal women. Expand
Early Regenerative Modifications of Human Postmenopausal Atrophic Vaginal Mucosa Following Fractional CO2 Laser Treatment
TLDR
The activation of regenerative mechanisms expressed both in the connective tissue - with the formation of new vessels, new papillae, and new collagen - and in the epithelium with the associated thickening and desquamation of cells at the mucosal surface are found. Expand
Light/Laser Applications in Gynecology
TLDR
The conclusion by reviewers is that outcomes and complication profiles of newer techniques compare favorably with the gold standard of endometrial resection. Expand
Microablative Fractional CO2 Laser for Vulvovaginal Atrophy in Women With a History of Breast Cancer: A Pilot Study at 4-week Follow-up.
TLDR
MLT was safe and effective in treating VVA symptoms in women with a history of BC, irrespective of being previously or currently on endocrine therapies, at 20-week follow-up. Expand
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