Histological progression of non-alcoholic fatty liver disease: a critical reassessment based on liver sampling variability.

@article{Ratziu2007HistologicalPO,
  title={Histological progression of non-alcoholic fatty liver disease: a critical reassessment based on liver sampling variability.},
  author={Vlad Ratziu and Elisabetta Bugianesi and J Dixon and Eduardo Fassio and Mattias Ekstedt and Fr{\'e}d{\'e}ric Charlotte and Stergios Kechagias and Thierry Poynard and R. Gran Olsson},
  journal={Alimentary pharmacology & therapeutics},
  year={2007},
  volume={26 6},
  pages={821-30}
}
BACKGROUND In non-alcoholic fatty liver disease, histological lesions display a significant sampling variability that is ignored when interpreting histological progression during natural history or therapeutic interventions. AIM To provide a method taking into account sampling variability when interpreting crude histological data, and to investigate how this alters the conclusions of available studies. METHODS Natural history studies detailing histological progression and therapeutic trials… CONTINUE READING