Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load.

@article{Drachenberg2004HistologicalPO,
  title={Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load.},
  author={Cinthia B Drachenberg and John C. Papadimitriou and Hans Hellmuth Hirsch and Ravinder K. Wali and Clinton D Crowder and J. Nogueira and Charles B Cangro and Susan R. Mendley and Ayesa N. Mian and Emilio Ramos},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2004},
  volume={4 12},
  pages={2082-92}
}
Polyomavirus-associated nephropathy (PVAN) is a significant cause of allograft loss. The diagnosis requires allograft biopsy, but the impact of the histological features on diagnosis and outcome has not been described. We studied the distribution and extent of PVAN in 90 patients. Viral cytopathic changes, tubular atrophy/fibrosis and inflammation were semi-quantitatively scored and classified into histological patterns. The histological findings were correlated with viruria, viremia and graft… CONTINUE READING

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Viral cytopathic changes , tubular atrophy / fibrosis and inflammation were semi - quantitatively scored and classified into histological patterns .
Viral cytopathic changes , tubular atrophy / fibrosis and inflammation were semi - quantitatively scored and classified into histological patterns .
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