Histological findings in the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency.

@article{Kimura2010HistologicalFI,
  title={Histological findings in the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency.},
  author={Akihiko Kimura and Masayoshi Kage and Ikuo Nagata and Sotaro Mushiake and Toshihiro Ohura and Yusaku Tazawa and Shunichi Maisawa and Takeshi Tomomasa and Daiki Abukawa and Yoshiyuki Okano and Ryo Sumazaki and Masaki Takayanagi and Akiko Tamamori and Tohru Yorifuji and Yasuhiko Yamato and Kohji Maeda and Masami Matsushita and Toyojiro Matsuishi and Ken Tanikawa and Keiko Kobayashi and Takeyori Saheki},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2010},
  volume={40 4},
  pages={295-303}
}
AIM To characterize the histological features of the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), we studied specimens from 30 patients diagnosed with NICCD by genetically analyzing the SLC25A13 gene. METHODS Liver biopsy specimens were subjected to hematoxylin-eosin, Azan, and Berlin-blue staining. RESULTS Most specimens showed varying degrees of fibrosis. The degree of inflammation varied among the specimens, with half showing moderate or… CONTINUE READING

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