Histological features of the degenerating intervertebral disc in a goat disc-injury model.

@article{Zhang2011HistologicalFO,
  title={Histological features of the degenerating intervertebral disc in a goat disc-injury model.},
  author={Yejia Zhang and Susan L. Drapeau and Howard S. An and Dessislava Z. Markova and Brett A. Lenart and David Greg Anderson},
  journal={Spine},
  year={2011},
  volume={36 19},
  pages={1519-27}
}
STUDY DESIGN An in vivo study to develop a goat large-animal model for intervertebral disc (IVD) degeneration. OBJECTIVE To determine an optimal method for inducing goat IVD degeneration suitable for testing disc regeneration therapies. SUMMARY OF BACKGROUND DATA Although rodent, rabbit, and other small animal studies are useful, the narrow dimensions of IVDs in these species limit studies requiring injection of a relevant volume of therapeutics or implantation of engineered tissue… CONTINUE READING

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