Corpus ID: 28075191

Histological evidences of reparative and regenerative effects of beta-adrenoceptor agonists, clenbuterol and isoproterenol, in denervated rat skeletal muscle.

@article{Katoch2006HistologicalEO,
  title={Histological evidences of reparative and regenerative effects of beta-adrenoceptor agonists, clenbuterol and isoproterenol, in denervated rat skeletal muscle.},
  author={Surender S. Katoch and Asha Garg and Sushma Sharma},
  journal={Indian journal of experimental biology},
  year={2006},
  volume={44 6},
  pages={
          448-58
        }
}
The aim of this study was to determine the contribution of beta-adrenoceptor activation in the reconstruction of the structural and functional organization of denervated skeletal muscle. beta-agonists, clenbuterol (1.2 mg/kg body weight) and isoproterenol (2 mg/kg body weight), administration (daily oral administration; maximum 7 days) to normal innervated rats as well as denervated animals caused muscle hypertrophy. An increase in mean fiber diameter confirmed this stimulated growth both in… Expand
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References

SHOWING 1-10 OF 37 REFERENCES
Beta adrenoceptor agonists, clenbuterol, and isoproterenol retard denervation atrophy in rat gastrocnemius muscle: use of 3-methylhistidine as a marker of myofibrillar degeneration.
TLDR
Results seemed to suggest that the degeneration of cyto-contractile apparatus accompanying denervation atrophy is attenuated in the presence of beta adrenergic agonists, implying that these sympathomimetic drugs are capable of reversing denervationatrophy in rat gastrocnemius. Expand
Effects of clenbuterol and propranolol on muscle mass. Evidence that clenbuterol stimulates muscle beta-adrenoceptors to induce hypertrophy.
TLDR
Data from a single subcutaneous injection of clenbuterol hydrochloride to female Wistar rats produced a rapid increase in muscle cyclic AMP and lactate concentrations and a decrease in muscle glycogen concentrations, consistent with the hypothesis that clen buterol influences muscle growth via beta-adrenoceptor stimulation. Expand
Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation.
TLDR
The results indicate that the anabolic effects of clenbuterol are dependent on interaction with the beta 2-adrenoceptor, and a long duration of action appears to be required to induce the an metabolic effects ofbeta 2-agonists. Expand
Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes.
BACKGROUND Skeletal muscle assistance of the circulation for patients in end-stage heart failure requires electrical training of the latissimus dorsi flap to produce fatigue resistance. This processExpand
Effects of clenbuterol on skeletal muscle mass, body composition, and recovery from surgical stress in senescent rats.
TLDR
Clenbuterol stimulated recovery of skeletal muscle protein lost following pump implantation in senescent rats and had similar anabolic and catabolic effects in all age groups. Expand
Clenbuterol-induced fiber type transition in the soleus of adult rats
TLDR
The relative increase in the number of histochemically determined type II fibers and the emergence of the normally unexpressed type IIdx MHC isoform in the soleus suggest a clenbuterol-induced transition of muscle fiber phenotype as well as selective hypertrophy of the type 11 fibers. Expand
Early onset of the maximum protein anabolic effect induced by isoproterenol in chick skeletal and cardiac muscle.
TLDR
It is suggested that prolonged treatment of chicks produced changes that were not much different from those recorded immediately within a fortnight, and an increase in organ weight and total tissue proteins supported cardiac hypertrophy in chicks as a result of isoproterenol administration. Expand
Anabolic effects of the beta 2-adrenoceptor agonist salmeterol are dependent on route of administration.
TLDR
The results indicate that the potency of salmeterol in vivo is dependent on its route of administration and that slow-twitch muscles are less sensitive than mixed-fiber muscles to the anabolic effects of beta 2-adrenoceptor agonists. Expand
Effects of clenbuterol on contractile and biochemical properties of skeletal muscle.
TLDR
The data suggest that the clenbuterol-induced increase in muscle mass and maximal force generation is due to hypertrophy of both fast and slow fibers, and support the notion that beta-agonists may be beneficial in combating conditions that result in muscle wasting and dysfunction. Expand
Clenbuterol increases the expression of myogenin but not myoD in immobilized rat muscles.
TLDR
Dietary administration of the beta-adrenoceptor agonist clenbuterol (2 mg/kg diet), which has been shown to ameliorate muscle wasting in a wide range of atrophic conditions, also limited Muscle wasting in terms of weight, protein, and RNA in the immobilized plantaris muscles. Expand
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