Histological evaluation of AMPK signalling in primary breast cancer

  title={Histological evaluation of AMPK signalling in primary breast cancer},
  author={Sirwan M. Hadad and Lee Baker and Philip Roy Quinlan and Katherine E Robertson and Susan E. Bray and George S. Thomson and David Kellock and Lee Jordan and C. Purdie and David Grahame Hardie and Stewart Fleming and Alastair M. Thompson},
  booktitle={BMC Cancer},
AMP-activated protein kinase (AMPK) acts as a cellular fuel gauge that responds to energy stress by suppressing cell growth and biosynthetic processes, thus ensuring that energy-consuming processes proceed only if there are sufficient metabolic resources. Malfunction of the AMPK pathway may allow cancer cells to undergo uncontrolled proliferation irrespective of their molecular energy levels. The aim of this study was to examine the state of AMPK phosphorylation histologically in primary breast… CONTINUE READING


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AMP-activated protein kinase and energy balance in breast cancer.

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