Histological changes in a model of chronic heart failure induced by multiple sequential coronary microembolization in sheep.


AIM Valuable models of chronic heart failure to perform histological studies are scarce. The authors aimed at investigating histological changes of the heart, lung, liver and kidneys in a stable and reproducible animal model of chronic heart failure in sheep. METHODS In 8 sheep (N.=8, 77+/-2 kg) chronic heart failure was induced by multiple sequential… (More)