Histological changes caused by intralesional injection of a streptococcal preparation into bladder cancer.

  • K. Fujita
  • Published 1988 in Cancer detection and prevention


OK-432, a lyophilized preparation of Streptococcus pyogenes, was cystoscopically injected into bladder cancer to destroy cancer cells and to prevent recurrences. Marked reactions occurred such as stromal edema, vascular dilation, cancer cell exfoliation, and polymorphonuclear cell infiltration, succeeded by monocyte and lymphocyte infiltration with… (More)