Histological assessments for toxicity and functionalization-dependent biodistribution of carbon nanohorns.

@article{Tahara2011HistologicalAF,
  title={Histological assessments for toxicity and functionalization-dependent biodistribution of carbon nanohorns.},
  author={Yoshio Tahara and Jin Miyawaki and Minfang Zhang and Mei Yang and Iwao Waga and Sumio Iijima and Hiroshi Irie and Masako Yudasaka},
  journal={Nanotechnology},
  year={2011},
  volume={22 26},
  pages={265106}
}
Single-walled carbon nanohorns (SWNHs) intravenously administered to mice did not show severe toxicity during a 26-week test period, which was confirmed by normal gross appearance, normal weight gain and the lack of abnormality in the tissues on histological observations of the mice. SWNH biodistribution was influenced by chemical functionalization. Accumulation of SWNH in the lungs reduced as SWNH hydrophilicity increased; however, the most hydrophilic SWNHs modified with bovine serum albumin… CONTINUE READING

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