Histological assessment of skin damage by irritants: its possible use in the evaluation of a ‘barrier cream’

  title={Histological assessment of skin damage by irritants: its possible use in the evaluation of a ‘barrier cream’},
  author={Gehan Adel Mahmoud and J. M. Lachapelle and Dominique van Neste},
  journal={Contact Dermatitis},
The histological changes induced by topical application of selected irritants are reported. The possible application of this methodology to the evaluation of the protective value of a silicone‐containing barrier cream is discussed. Although this crude method only allows objectivity of the later stages of a toxic reaction, it gives useful information about the potential protective effect of a silicone‐containing barrier cream. 
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In vivo and in vitro methods have been developed to evaluate BC efficacy, and recent bioengineering techniques provide more accurate quantitative data than supplied by traditional clinical studies dependent on visual scoring.
Effectiveness of Barrier Creams against Irritant Contact Dermatitis
Although this review highlights the poor quality and the lack of standardization of most studies, BCs seem to have protective effects against irritants, and vehicles seem to be as effective as BCs.
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The Textbook of Contact Dermatitis covers every conceivable aspect of modern day management of contact dermatitis, with special emphasis being given to occupational aspects as well as to prevention, diagnosis and treatment.
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The results suggest that there is a diversity and specificity in the histopathology of irritant contact dermatitis, reflecting the different ways in which chemicals may interact with components of the skin.
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    American journal of contact dermatitis : official journal of the American Contact Dermatitis Society
  • 1998
Biophysical Techniques for the Evaluation of Skin Protective Creams
While gloves and other protective garments are regularly worn when severely irritating substances such as concentrated acids or alkalis are handled, this is usually not the case with low level irritants.
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A new non‐irritant, non‐invasive method is introduced, based on evaluation of colour intensities when an aqueous solution of crystal violet is applied to the skin, after pretreatment with different creams, which may be used as a quick and easy test of the protective effect of creams against water.
Barrier Creams and Emollients
Skin protection in the workplace consists of preexposure BCs, mild skin cleansers and post-exposure skin-care products such as emollients or moisturizers, which are designed to prevent skin damage due to irritant contact.
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Considering the range of PC effects from good protection to increased irritation, depending on the irritant, the need for careful selection of PCs for specific workplaces is stressed.
Two novel techniques for the evaluation of barrier creams
Two tests based on the ability of a topically applied barrier preparation to prevent dyes from reaching the stratum corneum from filter paper discs in small aluminium chambers found to be usefully employed to assess the degree of efficacy of barrier cream preparations.


A method for the study of the effect of barrier creams and protective gloves on the percutaneous absorption of solvents.
Solvents were administered into closed skin depots on guinea pigs and the resulting blood concentrations were measured in samples repeatedly obtained via a catheter in the carotid artery. The exposure
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    Clinical and experimental dermatology
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The clinical dermatologist can scarcely avoid becoming involved in problems of occupational disease in the course of his professional life and must try to identify the offending agent as accurately as possible and assess whether this is behaving as an irritant or a sensitizer.
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Preliminary results obtained of five volunteers suggest that the application of a cream containing glycerol, stearates and oleostearates was not more effective and the interindividual variability in the total amount of m-xylene absorbed through the skin is greater than the intraindividual variability.
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The results are discussed in terms of occupational hazards and in relation to parallel studies on blood uptake and systemic toxicity at epicutaneous administration.
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