Histological assessment of skin damage by irritants: its possible use in the evaluation of a ‘barrier cream’

@article{Mahmoud1984HistologicalAO,
  title={Histological assessment of skin damage by irritants: its possible use in the evaluation of a ‘barrier cream’},
  author={Gehan Adel Mahmoud and J. M. Lachapelle and Dominique van Neste},
  journal={Contact Dermatitis},
  year={1984},
  volume={11}
}
The histological changes induced by topical application of selected irritants are reported. The possible application of this methodology to the evaluation of the protective value of a silicone‐containing barrier cream is discussed. Although this crude method only allows objectivity of the later stages of a toxic reaction, it gives useful information about the potential protective effect of a silicone‐containing barrier cream. 
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Barrier Creams and Emollients
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Considering the range of PC effects from good protection to increased irritation, depending on the irritant, the need for careful selection of PCs for specific workplaces is stressed.
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Two tests based on the ability of a topically applied barrier preparation to prevent dyes from reaching the stratum corneum from filter paper discs in small aluminium chambers found to be usefully employed to assess the degree of efficacy of barrier cream preparations.
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