Histological and histochemical characterisation of mammary gland tissue of cows infected with foot-and-mouth disease by contact exposure.

Abstract

Foot-and-mouth disease virus was observed to replicate in secretory epithelial cells of bovine mammary gland alveoli as a result of systemic infection initiated by exposure to infected animals. Viral antigens were demonstrated using fluorescent antibody and immunoperoxidase labelling techniques before the development of signs of clinical disease. In addition, labelled antigens were observed associated with cytoplasmic-like fragments in luminal membrane limited structures. Histologically, lesions of the alveolar secretory epithelium consisted of focal necrosis of these cells which eventually sloughed into the lumen.

Cite this paper

@article{Blackwell1983HistologicalAH, title={Histological and histochemical characterisation of mammary gland tissue of cows infected with foot-and-mouth disease by contact exposure.}, author={J H Blackwell and Patrick McKercher and Frank V. Kosikowski and Leland Eugene Carmichael and Ronald C Gorewit}, journal={Research in veterinary science}, year={1983}, volume={35 1}, pages={106-13} }