Histological Changes in Chinese Chronic Hepatitis B Patients with ALT Lower Than Two Times Upper Limits of Normal

@article{Chen2009HistologicalCI,
  title={Histological Changes in Chinese Chronic Hepatitis B Patients with ALT Lower Than Two Times Upper Limits of Normal},
  author={En-qiang Chen and Fei-jun Huang and Ling-li He and Lang Bai and Lichun Wang and Tao-you Zhou and Xue-zhong Lei and Cong Liu and Hong Tang},
  journal={Digestive Diseases and Sciences},
  year={2009},
  volume={55},
  pages={432-437}
}
The role of ALT as a predictor of liver injury has been questioned. The aim of this study is to use liver biopsy to assess the degree of liver injury in patients with chronic hepatitis B(CHB) whose ALT < 2 × upper limit of normal (ULN). A total of 49.2% of patients in this study had significant inflammation (grade ≥2) and 36.4% had significant fibrosis (stage ≥2). The frequency of serious inflammation and fibrosis was similar in patients with different ALT levels. The level of serum HBV DNA was… CONTINUE READING