Histologic versus molecular diagnosis of BK polyomavirus-associated nephropathy: a shifting paradigm?

@article{Drachenberg2006HistologicVM,
  title={Histologic versus molecular diagnosis of BK polyomavirus-associated nephropathy: a shifting paradigm?},
  author={Cinthia B Drachenberg and John C. Papadimitriou and Emilio Ramos},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2006},
  volume={1 3},
  pages={374-9}
}
Although discovered in 1970 the BK virus infections had no significant clinical impact until the emergence of BK virus-associated allograft nephropathy (BKPVAN). Escalating clinical challenges required better diagnostic tools and delineation of uniform criteria for diagnosis. In recent years, the widespread use of real-time PCR for measuring viral loads has confirmed that BK viruria and viremia are consistently identified before the development of overt nephritis. The identification of this… CONTINUE READING