Histologic transformation from adenocarcinoma to both small cell lung cancer and squamous cell carcinoma after treatment with gefitinib: A case report.

@article{Yao2018HistologicTF,
  title={Histologic transformation from adenocarcinoma to both small cell lung cancer and squamous cell carcinoma after treatment with gefitinib: A case report.},
  author={Yufeng Yao and Zhouyu Zhu and Yimin A. Wu and Ying Chai},
  journal={Medicine},
  year={2018},
  volume={97 18},
  pages={e0650}
}
RATIONALE In the past decade, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) treatment had been an important therapy for treating advanced EGFR-mutated lung cancer patients. However, a large number of these patients with EGFR-TKIs treatment always acquired resistance to these drugs in one year. The histologic transformation is an… CONTINUE READING