Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers.

@article{Just2012HistologicSI,
  title={Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers.},
  author={P A Just and Aur{\'e}lie Cazes and Anne Audebourg and Anatole Cessot and Karine Pallier and Claire Danel and Marie-C{\'e}cile Vacher-Lavenu and Pierre Laurent-Puig and Beno{\^i}t Terris and H{\'e}l{\`e}ne Blons},
  journal={Lung cancer},
  year={2012},
  volume={76 3},
  pages={309-15}
}
EML4-ALK adenocarcinomas constitute a new molecular subgroup of lung tumours that respond very well to crizotinib, an ALK inhibitor. However, the diagnosis of ALK rearrangement in lung cancer is challenging. The aim of this study was to compare the diagnostic accuracy of five different methods in a series of 20 EGFR(wt/wt) lung adenocarcinomas from non- or light- smokers. Multiplex RT-PCR was considered as gold standard and identified four ALK-rearranged tumours among the 20 tested tumours. qRT… CONTINUE READING

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