Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study.

@article{Gupta2007HistologicII,
  title={Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study.},
  author={Roopali Bansal Gupta and Noam H Harpaz and Steven H. Itzkowitz and Sabera Hossain and Sierra Matula and Asher A Kornbluth and Carol A. Bodian and Thomas Ullman},
  journal={Gastroenterology},
  year={2007},
  volume={133 4},
  pages={1099-105; quiz 1340-1}
}
BACKGROUND & AIMS Although inflammation is presumed to contribute to colonic neoplasia in ulcerative colitis (UC), few studies have directly examined this relationship. Our aim was to determine whether severity of microscopic inflammation over time is an independent risk factor for neoplastic progression in UC. METHODS A cohort of patients with UC undergoing regular endoscopic surveillance for dysplasia was studied. Degree of inflammation at each biopsy site had been graded as part of routine… CONTINUE READING
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