Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression.

@article{Attygalle2007HistologicEO,
  title={Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression.},
  author={Ayoma Deepthi Attygalle and Charalampia Kyriakou and Jehan Dupuis and Karen Lynne Grogg and Timothy Charles Diss and Andrew Charles Wotherspoon and Shih Sung Chuang and Jos{\'e} Manuel Valente Sequeira Cabeçadas and Peter Gershon Isaacson and Ming-Qing Du and Philippe Gaulard and A. Latif Dogan},
  journal={The American journal of surgical pathology},
  year={2007},
  volume={31 7},
  pages={1077-88}
}
Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon, but aggressive nodal peripheral T-cell lymphoma. Little is known of its biology and its natural history has been poorly studied. We report the first comprehensive study on the natural history/histologic progression of AITL by reviewing consecutive biopsies in 31 cases. Immunostaining for CD3, CD20, CD10 and CD21, CD23, CNA-42, CD4, CD8, and Ki 67, in situ hybridization for Epstein-Barr virus (EBV)-encoded RNA and polymerase chain… CONTINUE READING

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