Corneal vesicles accumulate collagen VI associated with tissue remodeling in apolipoprotein a-I deficiency: a case report
PURPOSE To report the histology of a cornea in a patient with apolipoprotein A-I (apoA-I) deficiency. METHODS A cornea from a patient with apoA-I deficiency was obtained by keratoplasty and examined histologically. RESULTS There were many small vesicles in the extracellular matrix throughout the corneal stroma. The vesicles were round or oval, and their diameters ranged from 200 nm to 2 microm. These histologic properties suggest that the small vesicles are lipid droplets. CONCLUSIONS Myriad lipid droplets in the extracellular matrix in the corneal stroma induce diffuse corneal opacity in a patient with apoA-I deficiency.