Histologic considerations for individualized systemic therapy approaches for the management of non-small cell lung cancer.

@article{West2009HistologicCF,
  title={Histologic considerations for individualized systemic therapy approaches for the management of non-small cell lung cancer.},
  author={Howard Jack West and David H. Harpole and William D Travis},
  journal={Chest},
  year={2009},
  volume={136 4},
  pages={1112-1118}
}
Over the past 5 to 10 years, we have reached a treatment plateau using standard platinum-based doublets in an unselected population of patients with advanced non-small cell lung cancer (NSCLC). Recent studies have focused on improving patient outcomes with new chemotherapeutic or targeted agents, as well as on individualizing therapy on the basis of patient characteristics such as tumor histology and biomarker analysis. This article summarizes recent data on histologic response determinants to… CONTINUE READING