Histologic changes in the spleen of rabbits following long-term and multiple immunization with sheep red blood cells.

Abstract

Results of immunologic and histologic studies on rabbits immunized with sheep red blood cells (SRBC) showed dependence of the immunologic response (PFC, RFC) on the histologic structure of the spleen, particularly width of the sinusoidal vessels. Histologic changes in the spleen are a result of immunization and their intensity is related to the dose of… (More)

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