Histologic assessment of nerve regeneration in the rat.

  title={Histologic assessment of nerve regeneration in the rat.},
  author={Susan E. Mackinnon and Arnold R. Hudson and Daniel A. Hunter},
  journal={Plastic and reconstructive surgery},
  volume={75 3},
This study reports the degree of spontaneous regeneration that will occur in the sciatic nerve of a rat 5 months after complete resection of the nerve. In 30 animals, the sciatic nerve was excised. Histological assessment at 5 months revealed evidence of regeneration for a variable distance (mean 23.7 mm +/- 6.4 mm). Histological sections were studied at 1-cm intervals along the length of the nerve. Evidence of compartmentation with "minifascicle" formation was noted. The orientation of the… CONTINUE READING