Histologic and cell kinetic studies of hair loss and subsequent recovery process of human scalp hair follicles grafted onto severe combined immunodeficient mice.

@article{Hashimoto2000HistologicAC,
  title={Histologic and cell kinetic studies of hair loss and subsequent recovery process of human scalp hair follicles grafted onto severe combined immunodeficient mice.},
  author={Takao Hashimoto and Tomohiko Kazama and Mayumi Ito and Kyoko Urano and Yuko Katakai and Noriko U. Yamaguchi and Y. Ueyama},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={115 2},
  pages={200-6}
}
To establish a model for studying human scalp hair, individually isolated hair follicles were grafted onto back skin of severe combined immunodeficient mice. Histologic changes and cell kinetics in the hair loss and subsequent recovery process were investigated. In the dystrophic stage (from day 7 to 30), all the hair shafts became dystrophic and were shed. Thickening and corrugation of vitreous membrane, apoptosis, and regression of the lower part were observed in the grafted hair follicles. 5… CONTINUE READING

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