Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort.

@article{McKenney2016HistologicGO,
  title={Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort.},
  author={Jesse K McKenney and Wei Wei and Sarah J. Hawley and Heidi Auman and Lisa F. Newcomb and Hilary D Boyer and Ladan Fazli and Jeff Simko and Antonio Hurtado-coll and Dean A. Troyer and Maria Tretiakova and Funda Vakar-Lopez and Peter R. Carroll and Matthew R. Cooperberg and Martin E. Gleave and Raymond S Lance and Dan W Lin and Peter S. Nelson and Ian M. Thompson and Lawrence D. True and Ziding Feng and James D Brooks},
  journal={The American journal of surgical pathology},
  year={2016},
  volume={40 11},
  pages={
          1439-1456
        }
}
Histologic grading remains the gold standard for prognosis in prostate cancer, and assessment of Gleason score plays a critical role in active surveillance management. We sought to optimize the prognostic stratification of grading and developed a method of recording and studying individual architectural patterns by light microscopic evaluation that is independent of standard Gleason grade. Some of the evaluated patterns are not assessed by current Gleason grading (eg, reactive stromal response… CONTINUE READING
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