Histologic Characterization of Canine Dilated Cardiomyopathy

@article{Tidholm2005HistologicCO,
  title={Histologic Characterization of Canine Dilated Cardiomyopathy},
  author={Anna Tidholm and Lennart J{\"o}nsson},
  journal={Veterinary Pathology},
  year={2005},
  volume={42},
  pages={1 - 8}
}
Dilated cardiomyopathy (DCM), characterized by chamber dilatation and myocardial systolic and diastolic dysfunction, is one of the most common heart diseases in dogs. [...] Key Result Review of reports on histologic findings in dogs with clinically diagnosed DCM reveals two histologically distinct forms of DCM: 1) cardiomyopathy of Boxers and Doberman Pinschers, corresponding to the “fatty infiltration-degenerative” type and 2) the form seen in many giant, large-, and medium-sized breeds, including some Boxers…Expand
Histologic comparison in two Doberman pinschers with a dilated cardiomyopathy phenotype.
TLDR
The value of considering alternative etiologies for DCM to guide additional clinical evaluation and owner counseling is highlighted and thoracic radiographs, echocardiography, and post-mortem histopathology images obtained from two Doberman pinschers are presented. Expand
Histologic Characterization of Dilated Cardiomyopathy in Estrela Mountain Dogs
TLDR
It is concluded that quantification of fibrosis and observation of AWFs in the left ventricular myocardium are useful in the histologic diagnosis of DCM in Estrela Mountain dogs. Expand
A comparison of the histopathologic pattern of the left atrium in canine dilated cardiomyopathy and chronic mitral valve disease
TLDR
The obtained results indicate a different nature of changes occurring in the left atrial myocardium of dogs with DCM compared to dogs with mitral valve disease, including differences in vessel narrowing, cardiomyocyte degeneration and in the distribution of connective tissue. Expand
Histological Characterization of Dilated Cardiomyopathy in the Juvenile Toy Manchester Terrier
TLDR
The presence of these myocardial lesions among closely related dogs suggests a genetic contribution to this disease process in the TMT, and the absence of parvoviral antigen does not rule out a possible viral or autoimmune cause. Expand
Associations between cardiac pathology and clinical, echocardiographic and electrocardiographic findings in dogs with chronic congestive heart failure.
TLDR
Data from this study lend support to the hypothesis that naturally occurring canine CHF is affected by several factors such as MMVD, myocardial atrophy and fibrosis, and by arteriosclerosis. Expand
The immunohistochemical evaluation of selected markers in the left atrium of dogs with end-stage dilated cardiomyopathy and myxomatous mitral valve disease – a preliminary study
TLDR
During heart failure, the pattern of desmin, vimentin, periostin and caspase-3 expression alters in the left atrium, regardless of the cause, suggesting that volume overload may not be the only cause of myocardial changes in DCM. Expand
Canine Dilated Cardiomyopathy: Diffuse Remodeling, Focal Lesions, and the Involvement of Macrophages and New Vessel Formation
TLDR
The present study characterized the diffuse myocardial remodeling processes that occur in canine DCM, investigating morphological changes in association with the expression of relevant cytokines and remodeling markers. Expand
Dilated Cardiomyopathy in Standard Schnauzers: Retrospective Study of 15 Cases.
TLDR
The occurrence of early onset DCM in multiple closely related standard schnauzers suggests a familial predisposition in this breed. Expand
Pathomorphological Changes of the Myocardium in Canine Dilated Cardiomyopathy (DCM)
TLDR
It was not determined whether the processes occurring in the myocardium have a primary character, or are a consequence of developing heart failure, but such issues will be put under further and more detailed examination. Expand
Cardiomyocyte marker expression in dogs with left atrial enlargement due to dilated cardiomyopathy or myxomatous mitral valve disease.
TLDR
The observed changes in the expression patterns of some proteins in the atria of dogs with DCM and MMVD suggest that atrial enlargement relies not only on volume overload, but also alterations of the intrinsic proteins can contribute to the pathogenesis of dilated cardiomyopathy. Expand
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