Histologic, immunohistochemical, and molecular classification of 52 IPMNs of the pancreas.

@article{Chadwick2009HistologicIA,
  title={Histologic, immunohistochemical, and molecular classification of 52 IPMNs of the pancreas.},
  author={Barbara E. Chadwick and Carlynn Willmore-Payne and Sheryl R. Tripp and Lester J Layfield and Sharon L. Hirschowitz and Joseph A. Holden},
  journal={Applied immunohistochemistry & molecular morphology : AIMM},
  year={2009},
  volume={17 1},
  pages={
          31-9
        }
}
BACKGROUND Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas account for approximately 5% of pancreatic neoplasms. Prognosis is superior to that of pancreatic invasive ductal carcinoma. IPMNs reveal a variety of epithelial linings expressing different mucin staining patterns and may progress along different oncogenic pathways. MATERIALS AND METHODS Fifty-two IPMNs were studied for expression of MUC1, MUC2, p16, p21, HER2, cyclin D1, and p53 protein and for mutations in K-ras… CONTINUE READING
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