Histogenesis of mouse cerebellum in microwell cultures. Cell reaggregation and migration, fiber and synapse formation

@article{Trenkner1977HistogenesisOM,
  title={Histogenesis of mouse cerebellum in microwell cultures. Cell reaggregation and migration, fiber and synapse formation},
  author={Ekkhart Trenkner and Richard L. Sidman},
  journal={The Journal of Cell Biology},
  year={1977},
  volume={75},
  pages={915 - 940}
}
A microwell culture system was developed for analysis of cell movements and interactions during nervous system histogenesis. Cells from trypsinized 7-day-old mouse cerebellum reaggregated within hours into clusters which later developed interconnections consisting of either sheets of migrating cells and cell processes or cables of fiber bundles with cells migrating along their surfaces. Granule cells in several stages of differentiation, basket and/or stellate neurons, some larger neurons, and… CONTINUE READING

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