Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands: An ultrastructural and immunohistochemical study

  title={Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands: An ultrastructural and immunohistochemical study},
  author={Robert A. Erlandson and Carlos Cardon‐Cardo and Paul J. Higgins},
  journal={The American Journal of Surgical Pathology},
Twenty-two benign pleomorphic adenomas of the major salivary glands were studied by transmission electron microscopy and immunohistochemical techniques (three cases) in order to characterize the cell types comprising the epithelial and so-called mesenchymal regions of the tumors. Light- and electron-microscopic studies showed the tumors to consist of variable mixtures of neoplastic ductular epithelial cells, rare acinar cells, and metaplastic myoepithelial cells. Many of the loosely organized… 

Salivary gland myoepithelioma variants

  • Irving DardickSharon Cavell B. Burns
  • Medicine, Biology
    Virchows Archiv A
  • 2005
Most described myoepitheliomas have a solid growth pattern and are composed of spindle and plasmacytoid cells, but based on cytological features and growth patterns in this series, it is apparent that polygonalshaped cells with novel architecture can occur in myoEPit Heliomas.

Basal cell adenoma with myoepithelial cell-derived "stroma": a new major salivary gland tumor entity.

This form of tubular-trabecular basal cell adenoma displays tricellular differentiation and, perhaps, may be considered either a hybrid basal cellAdenoma and myoepithelioma or a cellular pleomorphic adenomas.

Spindle‐cell adenomyoepithelioma of the breast a microscopic, ultrastructural, and immunocytochemical study

The authors believe the adenomyoepitheliomas described here are benign, well circumscribed without invasion of adjacent breast, contained neither mitotic figures nor cytologic atypia, and have not recurred or metastasized (6 and 10 months after removal).

The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma.

Immunoreactivity for these 3 smooth muscle-specific proteins confirms the known neoplastic myoepithelial component of adenoid cystic carcinomas and epithelial-myoEPithelial carcinomas, and consistently positive staining pattern in adenoids cystic cancer may be diagnostically useful in discriminating histologically similar but consistently negative polymorphous low-grade adenocarcinomas.

The ultrastructural aspects of neoplastic myoepithelial cell in pleomorphic adenomas of salivary glands

The analysis has proved the proliferation of two major cellular populations, one of ductal type and one of myoepithelial type, which tried to reproduce the tubulo‐acinar cytoarchitecture from the normal salivary glands.

Ultrastructural contributions to the study of morphological differentiation in malignant mixed (pleomorphic) tumors of salivary gland

Five examples of various histologic types of malignant mixed tumor of parotid origin were examined by electron microscope to see if underlying patterns of tumor cell differentiation and organization matched those of pleomorphic adenoma.