Histogenesis and morphology of naturally occurring prostatic carcinoma in the ACI/segHapBR rat.

@article{Ward1980HistogenesisAM,
  title={Histogenesis and morphology of naturally occurring prostatic carcinoma in the ACI/segHapBR rat.},
  author={Jerrold M Ward and Gerd Reznik and Sherman F. Stinson and Charles P Lattuada and D G Longfellow and T P Cameron},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1980},
  volume={43 6},
  pages={517-22}
}
The prostates of 201 male virgin or breeder ACI (ACI/segHapBR) rats, 24 to 40 months of age were reviewed histologically, and the genesis of prostatic carcinoma was studied. At 24 months of age, 35 to 45 per cent of the rats had the earliest lesions, intraalveolar atypical hyperplasias. These lesions progressed to intraalveolar cribriform carcinomas which spread along alveoli and ducts. As the tumors enlarged, they became nodular and invaded the capsule or adjacent tissues. By 33 months, 95 to… CONTINUE READING

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