Histochemistry of small intestinal dysplasia in familial polyposis coli

  title={Histochemistry of small intestinal dysplasia in familial polyposis coli},
  author={Paolo Romagnoli and Francesca Nardi and Francesco Tonelli and P Bechi},
  journal={Virchows Archiv B},
SummaryBiopsies of duodenal and ileal mucosa from patients with familial polyposis coli were studied. Areas of atypia were identified in the duodenum of six patients and in the ileum of three patients. Grade I atypia was characterized by crowding and elongation of cells and nuclei, a slight reduction in the number of goblet cells and the presence of a brush border; grade II atypia was further characterized by pseudoor pluristratification of cells, a marked reduction in the number of goblet… 
Duodenal adenomas in familial adenomatous polyposis: their structure and cellular composition with particular reference to endocrine hyperplasia
Based on histological criteria it is concluded that the risk of carcinoma development in the duodenum could equal that in colon and rectum.
Mucin histochemistry of virus-induced duodenal adenomas in guinea fowl
The histochemical study carried out supplemented the histological characterization of the virus-induced duodenal adenomas and contributed to the elucidation of some aspects of their histogenesis.


Grades of atypia in tubular and villous adenomas of the human colon
  • H. Gabbert, P. Höhn
  • Medicine
    Virchows Archiv. B, Cell pathology including molecular pathology
  • 1980
In the cytoplasm of adenoma cells with atypia grade II, glycogen storage is found as a special feature which does not occur in normal colonic epithelium and can be regarded as a further indication of the precancerous nature of the adenomas.
Comparative study of familial polyposis coli and nonpolyposis coli on the histogenesis of large-intestinal adenoma
The entire length of the large intestine resected from six patients with familial polyposis coli (FPC) was step-sectioned, and microscopic adenomas composed of one to several glands were prepared into complete serial sections and it is believed that the morphologic difference of thelarge-intestinal mucosa between FPC and nonpolyposis bacteria comes from the difference in the position and/or timing of appearance ofAdenomas.
Patterns of mucus secretion in the colonic epithelium in familial polyposis.
Patterns of mucus secretion were investigated, by histochemical methods, in 24 colectomy specimens resected for familial polyposis coli, suggesting a relationship between altered glycoprotein synthesis and malignancy.
Studies on the difference of background mucosa among single advanced carcinoma and benign diseases of the large intestine, and familial polyposis coli
The findings indicate that the colonic mucosa of patients in the Cancer and Benign Groups is similar, but differs from that of the Polyposis Group, and that microscopic adenomas are not uncommon in the Non‐Polyposis Groups (Cancer andBenign Groups), findings which were not previously known.
Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres.
The results suggest that intestinal metaplasia types may have different malignant potential and their identification may be useful in screening patients for early detection of cancer.
A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study
A variant of IM, with extensive involvement of both antrum and body and excessive secretion of sulphomucin, was found to be associated with carcinomas showing appreciable extracellular sulphomUCin secretion.
Mucin histochemistry and questions in gastroenterology.
  • A. Gad
  • Medicine
    Scandinavian journal of gastroenterology. Supplement
  • 1979
Five main problems in the filed of gastroenterology are discussed; namely: 1) The nature of intestinal metaplasia and histogenesis of adenocarcinoma of the stomach, 2) Early diagnosis of small intestinal carcinoma, 3) The so called transitional colonic mucosa, 4) The diagnosis of ulcerative colitis and Crohn's disease and 5) Differential diagnosis of other carcinomas growing into the large bowel.