Histochemische Untersuchungen der Cancerogenese in der Rattenleber nach Dauergaben von Diäthylnitrosamin

Abstract

Female rats (Sprague-Dawley) were periodically injected with one of four doses (2.8 mg/kg to 14 mg/kg) of diethylnitrosamine. Almost all liver carcinomas that appeared after months lacked glucose-6-phosphatase as measured histochemically. At all doses clearly delineated islands of cells without glucose-6-phosphatase were observed long before carcinomas… (More)
DOI: 10.1007/BF00524337

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