Histochemical observations on rodent brain melanin

@article{Barden1983HistochemicalOO,
  title={Histochemical observations on rodent brain melanin},
  author={Herbert Barden and Seymour Levine},
  journal={Brain Research Bulletin},
  year={1983},
  volume={10},
  pages={847-851}
}
The presence or absence of melanin and neuromelanin in rodent brain was determined by means of light microscopic histochemistry. Melanin in melanocytes located in meninges and along cerebral capillaries occurred in abundance in C57 black mice and to a lesser extent in pigmented rats. Meningeal melanin bound cupric and ferrous ions, reduced ferricyanide, and appeared golden-brown in the bright field, light scattering in the dark field, and absorbant in the ultraviolet. Eleven aging albino rats… Expand
Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease
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Comparing what is known about neuromelanin with melanins found in other body tissues suggests that this proposed function may be compromised, thus rendering pigmented neurons vulnerable to oxidative damage in this disorder. Expand
Meningeal Melanocytes in the Mouse: Distribution and Dependence on Mitf
TLDR
The distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain are described and it is confirmed that they are melanocytes, which are pigment producing cells derived from the neural crest. Expand
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TLDR
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The intragranular location of carboxyl groups in neuromelanin and lipofuscin in human brain and in meningeal melanosomes in mouse brain.
  • H. Barden
  • Biology, Medicine
  • The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1986
TLDR
The intragranular location of carboxyl groups was tinctorially determined in human substantia nigra neuromelanin granules, human inferior olive lipofuscin granule, and mouse meningeal melanosomes and the following structural and chemical basis was proposed for the different resistance of Nile blue staining of melanosome and of neuromalanin and lip ofuscin to acetone extraction. Expand
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Several studies indicate that neuromelanin may play a significant role both in the initiation and in the progression of neurodegeneration, and shows that the toxicological implications of the accumulation of toxicants in pigmented neurons and its possible role in neurodegenersation should not be neglected. Expand
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Comparative aspects of the biology of neuromelanin and lipofuscin are presented, as well as a discussion of their hypothesized functions in brain and their possible roles in aging and neurodegenerative disease. Expand
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TLDR
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Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin – A critical review
TLDR
Sepia melanin is presented as the most appropriate study model for the binding characteristics of neuromelanin based on chemical structure, surface characteristics and structural features of both synthetic and organic melanins. Expand
Interaction between chemicals and melanin.
  • B. Larsson
  • Biology, Medicine
  • Pigment cell research
  • 1993
TLDR
Various drugs and other chemicals, such as organic amines, metals, polycyclic aromatic hydrocarbons, etc., are bound to melanin and retained in pigmented tissues for long periods and there are many indications of a connection between the melanin affinity of these agents and the induction of malignant melanoma. Expand
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