Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease
- BiologyProgress in Neurobiology
Meningeal Melanocytes in the Mouse: Distribution and Dependence on Mitf
- Biology, MedicineFront. Neuroanat.
The distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain are described and it is confirmed that they are melanocytes, which are pigment producing cells derived from the neural crest.
The intragranular location of carboxyl groups in neuromelanin and lipofuscin in human brain and in meningeal melanosomes in mouse brain.
- Biology, ChemistryThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
The intragranular location of carboxyl groups was tinctorially determined in human substantia nigra neuromelanin granules, human inferior olive lipofuscin granule, and mouse meningeal melanosomes and the following structural and chemical basis was proposed for the different resistance of Nile blue staining of melanosome and of neuromalanin and lip ofuscin to acetone extraction.
Melanin affinity and its possible role in neurodegeneration
- Biology, ChemistryJournal of Neural Transmission
Several studies indicate that neuromelanin may play a significant role both in the initiation and in the progression of neurodegeneration, and shows that the toxicological implications of the accumulation of toxicants in pigmented neurons and its possible role in neurodegenersation should not be neglected.
The comparative biology of neuromelanin and lipofuscin in the human brain
- BiologyCellular and Molecular Life Sciences
Comparative aspects of the biology of neuromelanin and lipofuscin are presented, as well as a discussion of their hypothesized functions in brain and their possible roles in aging and neurodegenerative disease.
Melanin and neuromelanin binding of drugs and chemicals: toxicological implications
- Biology, ChemistryArchives of Toxicology
An overview of melanin binding of drugs and other compounds, and possible toxicological implications, with particular focus on the central nervous system and its potential involvement in neurodegenerative disorders is provided.
Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin – A critical review
- BiologyJournal of Chemical Neuroanatomy
Catecholaminergic neurons of mammalian brain and neuromelanin
- BiologyJournal of Evolutionary Biochemistry and Physiology
In the presented review there are generalized and analyzed novel data about structure and functions of neuromelanin, as well as discussed is its possible role in pathogenesis of Parkinson’s disease.
The location of heart melanocytes is specified and the level of pigmentation in the heart may correlate with coat color
- Medicine, BiologyPigment cell & melanoma research
Analysis of the localization of heart melanocytes and their levels of pigmentation in a series of mutant mice found that melanocytes were localized in the valves and septa of the heart and appears to reflect that of the skin.
Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells
- BiologyJournal of Neural Transmission
The data suggest that accumulation of a neurotoxicant in melanin-loaded cells may lead to increased cell stress, apoptotic signaling and disassociation of melanin aggregates.
SHOWING 1-10 OF 21 REFERENCES
Light and electron microscopic studies of pigment in human and rhesus monkey substantia nigra and locus coeruleus
- BiologyThe Anatomical record
Neuromelanin pigment of the substantia nigra and locus coeruleus from nine human autopsy cases and from four rhesus monkeys was studied and no evidence of silver reduction was noted in lipofuscin pigment.
PIGMENT AND PIGMENT TUMORS: BIOCHEMICAL BASIS OF HUMAN MELANIN PIGMENTATION
During this period there was a vigorous controversy over the mechanism of melanin formation in man, since tyrosinase could not be demonstrated in mammalian tissue.
RELATIONSHIP OF GOLGI THIAMINEPYROPHOSPHATASE AND LYSOSOMAL ACID PHOSPHATASE TO NEUROMELANIN AND LIPOFUSCIN IN CEREBRAL NEURONS OF THE AGING RHESUS MONKEY
- Biology, ChemistryJournal of neuropathology and experimental neurology
The results suggest that neuromelanin accumulates in the presence of an intact Golgi apparatus; this is the converse of what happens following the accumulation of lipofusein in the nerve cell in which a functional depression in the Gol Gi apparatus related to aging appears to occur.
Melanin content of hamster tissues, human tissues, and various melanomas.
- BiologyCancer research
The purpose was to evaluate the possible efficacy of chlorpromazine, which is known to bind to melanin, as a vehicle for boron transport in neutron capture therapy.
Genetic Variations in the Fine Structure and Ontogeny of Mouse Melanin Granules.
The path along which a melanocyte from a hair follicle is differentiating may be altered at the level of aggregation of newly-synthesized protein, a fact which has interesting implications regarding embryonic induction.
The fine structure of the neurons in the rat substantia nigra.
- BiologyTissue & cell
MELANOMA IN AN ALBINO.
- Medicine, BiologyJAMA
It appears that the melanocyte is necessary for the development of this cancer, but the metabolic pathway for melanin production is not, and the latter is a guide to the chemotherapeutic control of melanomas.
Clinical, morphologic, and neurochemical aspects in the aging central nervous system
Este livro contém os relatórios apresentados ao V I Simpósio Internacional sobre Fluxo Sangüíneo Cerebral, realizado em Filadelfia entre 6 e 9 de junho de 1 9 7 3 . Atenção especial foi focalizada no…