Histochemical detection of apoptosis in Parkinson's disease

  title={Histochemical detection of apoptosis in Parkinson's disease},
  author={Hideki Mochizuki and Keigo Goto and Hideo Mori and Yoshikuni Mizuno},
  journal={Journal of the Neurological Sciences},
Apoptosis in neurodegenerative disorders.
It is suggested that apoptosis is involved in nigral cell cleath in PD at least in part and warrant further studies on apoptosis-related substances in PD.
On the question of apoptosis in the parkinsonian substantia nigra
The results fail to demonstrate apoptosis as a mechanism of cell death in Parkinson’s disease.
Apoptosis and Parkinson's disease
Does neuronal loss in Parkinson's disease involve programmed cell death?
  • J. Andersen
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2001
A picture is emerging, however, that strongly suggests that many of the molecular players thought to participate in this type of neuronal cell death are active in Parkinson's disease.
Inflammatory Changes and Apoptosis in Parkinson’s Disease
Analysis of human subjects intoxicated by 1-methyl-4-phenyl-1,2,3,6,6,-tetrahydropyridine suggests that MPTP, having induced a primary insult to dopaminergic neurons set in motion a self-perpetuating phenomenon leading to a progressive loss of dopamine neurons.
Cell death and apoptosis regulating proteins in Parkinson’s disease – a cautionary note
Findings do not support the hypothesis that apoptosis plays a central role in the pathogenesis of PD and no significant changes of any of the apoptosis regulating proteins were apparent in PD substantia nigra.
Apoptosis, Neurotrophic Factors and Neurodegeneration
The evidence implicating apoptosis in neurodegenerative diseases with a particular emphasis on Alzheimer's disease is described, with strong evidence from human brain studies, transgenic models and in vitro models to suggest that the mode of nerve cell death is apoptotic.
Apoptosis: its relevance to Parkinson's disease


In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
Evidence of DNA fragmentation in cells in temporal cortex and hippocampus from patients with AD and in striatum from those with HD is found, suggesting that apoptosis may be involved in these disorders.
Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence.
Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease
The substantia nigra of 8 patients with Parkinson's disease immunohistochemically using antisera against complexes I, II, III, and IV of the mitochondrial electron transport system confirmed the findings that there is a deletion of gene coding for the four subunits in the mitochondrial DNA located in the striata of parkinsonian patients.
Apoptosis and disease
Point mutations of mitochondrial genome in Parkinson's disease.
Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.
These studies show that both in situ nick translation and in situ tailing are useful in detecting DNA fragmentation in cell suspensions and tissue sections and may help to define the molecular mechanisms leading to cell death in experimental conditions and eventually in human tissue.
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
The N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey provides a model that can be used to examine mechanisms and explore therapies of parkinsonism and the pathological and biochemical changes produced by NMPTP are similar to the well-established changes in patients with parkinsonistan.