Histochemical detection of apoptosis in Parkinson's disease.

  title={Histochemical detection of apoptosis in Parkinson's disease.},
  author={Hiroyuki Mochizuki and Kenji Goto and Hideo Mori and Yuji Mizuno},
  journal={Journal of the neurological sciences},
  volume={137 2},
Apoptosis may be an important mechanism of cell death in some experimental disease models as well as in human neurodegenerative disorders. We report evidence to indicate apoptosis in the substantia nigra of Parkinson's disease patients. We studied the midbrains of 7 patients with late onset PD, 4 patients with young onset PD and 6 control subjects using the nick-end labeling method. Intense nuclear staining indicating apoptotic process was observed in 8 out of 11 parkinsonian patients studied… CONTINUE READING