Histidylated cationic polyorganophosphazene/DNA self-assembled nanoparticles for gene delivery.

@article{Yang2008HistidylatedCP,
  title={Histidylated cationic polyorganophosphazene/DNA self-assembled nanoparticles for gene delivery.},
  author={Yongxin Yang and Zhenghong Xu and Shangwei Chen and Yu Gao and Wangwen Gu and Lingli Chen and Yuanying Pei and Yaping Li},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={353 1-2},
  pages={277-82}
}
Cationic polyorganophosphazene has shown the ability to deliver gene. To obtain more efficient transfection, His(Boc)-OMe bearing histidine moiety was introduced to synthesize a new derivative of cationic polyphosphazenes with another side group of 2-dimethylaminoethylamine (DMAEA). The poly(DMAEA/His(Boc)-OMe)phosphazene (PDHP) and DNA could self-assemble into nanoparticles with a size around 110 nm and zeta potential of +15 mV at the PDHP/DNA ratio of 10:1 (w/w). The maximum transfection… CONTINUE READING